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J Gen Virol 36 (1977), 317-321; DOI 10.1099/0022-1317-36-2-317
© 1977 Society for General Microbiology

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The Mechanism of the Inactivation of Human Fibroblast Interferon by Mechanical Stress

T. Cartwright, O. Senussi and Madeline D. Grady

Searle Research Laboratories, Lane End Road High Wycombe Bucks. HP12 4HL, U.K.

Interferon derived from human fibroblasts is readily inactivated during agitation and filtration. This inactivation has been shown to be largely a product of mechanical stress, and has been studied in detail by subjecting interferon to controlled shear stress using a rotational viscometer. The possible mechanism of this phenomenon is discussed.

Received 7 February 1977; accepted 15 March 1977.





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