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Treatment of Fatal Disseminated Vaccinia Virus Infection in Immunosuppressed Mice

Department of Medicine St Elizabeth's Hospital of Boston, Brighton Massachusetts 02135

M. Conliffe

Food and Drug Administration Bureau of Biologics, Division of Virology, Bethesda Maryland 20014, U.S.A.

Studies were performed to compare the therapeutic effectiveness of three antiviral drugs (ARA-A, ARA-C and IDU) on the course of fatal disseminated vaccinia virus infection in immunosuppressed mice. Treatment with ARA-A begun as late as 7 days after virus infection was significantly effective in preventing death; no antiviral effect of the other two drugs was demonstrated.

Received 16 July 1976; accepted 16 March 1977.

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