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Activation of an Endogenous C-Type RNA Virus in Rat Embryo Cells after Transformation by Herpes Simplex Virus Types 1 and 2

Institute for Virus Research German Cancer Research Centre, Im Neuenheimer Feld 280
^* Institute for Medical Virology University of Heidelberg, Im Neuenheimer Feld 324 6900 Heidelberg, W. Germany

Reverse transcriptase activity was detected in the supernatants of rat embryo fibroblast cell cultures transformed by HSV types 1 and 2 at either the sub-optimal temperature of 20 °C or the supra-optimal temperature of 42 °C. Rat cell clones which had been transformed at 20 °C contained higher levels of C-type virus DNA polymerase than did cell clones which had been transformed at 42 °C. Syncytia formation typical for C-type RNA viruses occurred at passages higher than 24. The activation of endogenous C-type RNA viruses was independent of the virus and transformation method used.

Received 7 March 1977; accepted 20 April 1977.