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The Effect of Temperature on the Synthesis of Rhinovirus Type 2 RNA

E. J. Stott

D. Lee

Clinical Research Centre, Watford Road, Harrow, U.K.

The reduced yields of rhinovirus type 2 at temperatures above 37 °C were shown to result from the degradation of virus-induced RNA, leaving little RNA available for inclusion into mature infectious virions. The degradation occurred about 6 h p.i., and appeared to be selectively effecting the single-stranded species. Lysosomal nucleases do not appear to have a role in this supra-optimal degradation.

^* Present address: Department of Microbiology, University of Leeds, Leeds LS2 9JT.

Present address: Institute for Research on Animal Disease, Compton, Newbury, Berks.

Present address: Department of Surgery, University of Otago, Dunedin, New Zealand.

Received 21 January 1977; accepted 7 April 1977.