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Some Properties of Recombinants Between Type 1 and Type 2 Herpes Simplex Viruses

Department of Microbiology, School of Medicine, Leeds, LS2 9NL

Four intertypic recombinants of herpes simplex virus have been shown to possess genetic information for functions characteristic of each of the two parental types. The functions were identified by (a) polyacrylamide gel electrophoresis of purified virus particles and of polypeptides synthesized in cells infected with the recombinants and (b) analysis of antigenic sites interacting with type specific neutralizing antibody. The analysis shows that each recombinant possesses a different combination of these type specific markers. Finally we have been unable to detect recombination between herpes simplex type 1 and pseudorabies viruses.

Received 25 February 1977; accepted 19 April 1977.

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