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Induction of Interferon in Human Lymphoblastoid Cells by Sendai and Measles Viruses

Department of Chemistry, Biology and Microbiology Limburgs Universitair Centrum, B-3610 Diepenbeek, Belgium

A. Billiau

Department of Human Biology Rega Institute University of Leuven, B-3000 Leuven, Belgium

Sendai and measles viruses were tested for their interferon-inducing capacity in human lymphoblast cells. Sendai virus reproducibly induced considerable amounts of interferon (1 research reference interferon unit/10³ cells), but no increase in infectious virus titre was observed. Two Edmonston–Enders strains of measles virus grew very well. The attenuated (A) strain was a good interferon inducer (4 units/10³ cells), while the virulent (V) strain induced only minimal amounts at a high multiplicity of infection. Pre-treatment of the cells with 5-iododeoxyuridine (IdUrd) had no effect on the growth of Sendai or EE measles virus and on interferon yields induced by Sendai virus. It slightly potentiated interferon induction by EE measles virus. Partial u.v.-light-inactivation of Sendai virus infectivity resulted in a parallel loss in interferon-inducing capacity.

Received 29 December 1976; accepted 27 May 1977.

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