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Repeated ‘Superinduction’ of Interferon in Human Diploid Fibroblast Cultures

Interferon Laboratories Sloan-Kettering Institute for Cancer Research, New York, New York 10021, U.S.A.

Human diploid fibroblast cultures induced to make interferon by the combination of polyriboinosinic acid-polyribocytidylic acid, cycloheximide and actinomycin D degenerate thereafter, owing to the irreversible nature of the inhibition induced by actinomycin D. However, cultures superinduced with the DNA-dependent RNA synthesis inhibitor 5,6-dichloro-1--D-ribofuranosylbenzimidazole (DRB) survive, owing to the reversible nature of the inhibition induced by DRB, and can again be superinduced on several occasions.

Received 30 May 1977; accepted 13 June 1977.