HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fleming, P. Search for Related Content PubMed PubMed Citation Articles by Fleming, P. Agricola Articles by Fleming, P.

Age-Dependent and Strain-Related Differences of Virulence of Semliki Forest Virus in Mice

Microbiological Research Establishment, Porton Down, Salisbury, Wilts, SP4 0JG

Factors that influence the virulence of Semliki Forest virus for mice have been studied. In vivo experiments showed that maximum brain infectivities following i.p. inoculation of adult mice with a virus strain of low virulence were less than those found in mice showing clinical signs in virulent infections. The virulent strains generally caused death before antibody could be detected in brain tissue; the less virulent strain caused an infection that was neuroinvasive, but infectivity increased less rapidly in the brain and allowed antibody to intervene before clinical signs were apparent. IgG3 antibody was first detected in brain tissue coincident with the beginning of the decline of brain infectivities in avirulent infections; other sub-classes of IgG antibody were not detected until later.

In vitro experiments showed differences in abilities of SFV strains to replicate in tissue culture and adult mouse brain tissue, and differences in susceptibility to infection of brain tissue from mice of various ages. These in vitro results could provide a basis for differences of virulence.

Received 28 March 1977; accepted 27 April 1977.

This article has been cited by other articles:

				M. Alsharifi, M. Lobigs, M. Regner, E. Lee, A. Koskinen, and A. Mullbacher Type I Interferons Trigger Systemic, Partial Lymphocyte Activation in Response to Viral Infection J. Immunol., October 1, 2005; 175(7): 4635 - 4640. [Abstract] [Full Text] [PDF]

				J. K. Fazakerley, A. Boyd, M. L. Mikkola, and L. Kaariainen A Single Amino Acid Change in the Nuclear Localization Sequence of the nsP2 Protein Affects the Neurovirulence of Semliki Forest Virus J. Virol., January 1, 2002; 76(1): 392 - 396. [Abstract] [Full Text] [PDF]

				H. P. Hefti, M. Frese, H. Landis, C. Di Paolo, A. Aguzzi, O. Haller, and J. Pavlovic Human MxA Protein Protects Mice Lacking a Functional Alpha/Beta Interferon System against La Crosse Virus and Other Lethal Viral Infections J. Virol., August 1, 1999; 73(8): 6984 - 6991. [Abstract] [Full Text]