HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rutter, G. Articles by Mannweiler, K. Search for Related Content PubMed PubMed Citation Articles by Rutter, G. Articles by Mannweiler, K. Agricola Articles by Rutter, G. Articles by Mannweiler, K.

Alterations of Actin-Containing Structures in BHK21 Cells Infected with Newcastle Disease Virus and Vesicular Stomatitis Virus

Heinrich-Pette-Institut für experimentelle Virologie und Immunologie an der Universität Hamburg, Martinistrasse 52, 2000 Hamburg 20, Federal Republic of Germany

The distribution pattern of actin-containing structures in BHK21 cells and the changes which they undergo upon infection with Newcastle disease virus (NDV) and vesicular stomatitis virus (VSV) were studied by means of immunofluorescence.

Double labelling with antibodies conjugated with fluorescein (for actin) and rhodamine (for virus antigens) has shown that the progressive cytopathic effects after virus infection are accompanied by extensive alterations of the structures demonstrable by antiactin antibodies. In NDV-infected BHK21 cells the number of actin filaments increases, some zones which contain virus antigens apparently being in close association with the actin structures. By contrast, infection with VSV results in a strong reduction of actin-containing fibres.

The results indicate that in the genesis of morphologically detectable alterations of a cell after virus infection — the ‘cytopathic changes’ — alterations of those structural elements are involved which are also probably responsible for maintenance of cell shape and motility.

Received 25 April 1977; accepted 25 May 1977.

This article has been cited by other articles:

				W. P. Duprex, S. McQuaid, and B. K. Rima Measles Virus-Induced Disruption of the Glial-Fibrillary-Acidic Protein Cytoskeleton in an Astrocytoma Cell Line (U-251) J. Virol., April 15, 2000; 74(8): 3874 - 3880. [Abstract] [Full Text]

				P. C. Roberts, T. Kipperman, and R. W. Compans Vesicular Stomatitis Virus G Protein Acquires pH-Independent Fusion Activity during Transport in a Polarized Endometrial Cell Line J. Virol., December 1, 1999; 73(12): 10447 - 10457. [Abstract] [Full Text]