HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Moldow, C. F. Articles by Lee, J. J. Search for Related Content PubMed PubMed Citation Articles by Moldow, C. F. Articles by Lee, J. J. Agricola Articles by Moldow, C. F. Articles by Lee, J. J.

Avian Tumour Virus Interactions with Chicken Fibroblast Membranes: Partial Characterization of Initial Attachment Site Activity

Michael McGrath

Department of Medicine, University of Minnesota Medical School Minneapolis, Minnesota 55455, U.S.A.

Exposure of chicken embryo fibroblasts (CEF) to trypsin solubilizes cell surface components, including the initial attachment site for avian tumour viruses (ATV). This soluble attachment site activity appears to interact directly with the ATV in vitro thereby interfering with the binding of at least two ATV subgroups to both intact CEF and CEF plasma membranes. A result of this interaction in vitro is reduced ATV infectivity, demonstrated by reduced transforming capacity of RSV (RAV-1).

^* Present address: University of Utah Medical School, Salt Lake City, Utah, U.S.A.

Present address: Stanford University Medical School, Palo Alto, California, U.S.A.

Received 26 April 1977; accepted 17 June 1977.