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J Gen Virol 38 (1978), 51-59; DOI 10.1099/0022-1317-38-1-51
© 1978 Society for General Microbiology
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Characteristics of Human Lymphoblastoid (Namalva) Interferon

E. A. Havell, Y. K. Yip and J. Vilcek

Department of Microbiology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, U.S.A.

Interferon derived from the human lymphoblastoid cell line, Namalva, was fractionated by antibody affinity chromatography into two antigenically distinct interferon subspecies. At least 13% of the total Namalva interferon activity possessed the F antigenic determinant found on human interferon derived from fibroblast cultures, while the bulk of the Namalva interferon activity had the Le antigenic determinant characteristic for human leukocyte interferon. The separated Le and F subspecies of Namalva interferon differed in the degree of their heterospecific activities on bovine cells. The Le moiety resembled crude leukocyte interferon in that it was highly active in bovine cells. The F component of Namalva interferon showed a lower degree of activity in bovine cells, thus resembling crude fibroblast interferon. When analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and by isoelectric focusing, crude Namalva interferon qualitatively resembled crude leukocyte interferon.

Received 21 June 1977; accepted 21 July 1977.


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Y. Yip, B. Barrowclough, C Urban, and J Vilcek
Molecular weight of human gamma interferon is similar to that of other human interferons
Science, January 22, 1982; 215(4531): 411 - 413.
[Abstract] [PDF]


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