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Inter-relationship Between Genes Controlling Endogenous Virus Expression and those Controlling Susceptibility to Exogenous RNA Tumour Viruses: Evidence for Linkage Between the Group Specific Antigen and Tumour Virus e Loci

Houghton Poultry Research Station, Houghton, Huntingdon, Cambs., PE17 2DA, England

A study using three inbred lines, Reaseheath C, HPRS-synthetic E and RPRL-7-2, was made to investigate the inter-relationship between the genes that regulate antigenic expression of the subgroup E endogenous virus and those that control susceptibility to infection with exogenous viruses of subgroups A, B and E.

It was found that the tumour virus e (tve) and group specific (gs) antigen loci are linked, as indicated by the non-random association between the genes at the two loci. On the other hand, the genes at the other three loci, tva, tvb and gs, segregate and recombine at random in accordance with Mendel's second law. That tvb and tve are two independently segregating loci, was also confirmed in this study. Furthermore, the evidence that the tve locus, while segregating independently of the tvb locus, is linked with the gs locus upheld the hypothesis of its existence contrary to the views of other workers. This study suggests that the gs locus could be used as a marker for the detection of the tve locus in chicken lines that lack the I^e gene. Also, it has been shown that the I^e gene is not identical to the gs⁺ gene contrary to our earlier hypothesis.

Received 6 January 1977; accepted 25 July 1977.