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The Specific Reduction of a and d Antigenic Determinants after Periodate Treatment of Hepatitis B Surface Antigen (HBsAg)

Department of Bacteriology, Tohoku University School of Medicine, Seiryomachi Sendai, Japan

T. Sekine

Virology Division, National Cancer Center Research Institute, Tsukiji, Chuoku, Tokyo, Japan

HBsAg antigenicity was found to be sensitive to periodate treatment. Antigenic determinants a and d were especially sensitive, losing almost all of their activity, while determinants r and w were found to be quite stable. Also, it is now possible to prepare the monospecific antibodies, anti-r and anti-w, by the use of this new, simpler procedure.

Received 21 June 1977; accepted 24 August 1977.

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				P Tiollais, P Charnay, and G. Vyas Biology of hepatitis B virus Science, July 24, 1981; 213(4506): 406 - 411. [Abstract] [PDF]