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J Gen Virol 38 (1978), 369-374; DOI 10.1099/0022-1317-38-2-369
© 1978 Society for General Microbiology
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Stable Transformation of Mouse, Rabbit and Monkey Cells and Abortive Transformation of Human Cells by BK Virus, a Human Papovavirus

Marinella Portolani and Mariangela Borgatti

Institute of Microbiology and Virology, University of Bologna, Via San Giacomo, 12, 40126 Bologna, Italy

Alfredo Corallini, Enzo Cassai, Maria Pia Grossi and Giuseppe Barbanti-Brodano

Institute of Microbiology, University of Ferrara, Via Luigi Borsari, 46, 44100 Ferrara, Italy

Laura Possati

Institute of Microbiology, University of Ancona, Via Grotte di Posatora, 60100 Ancona, Italy

Semi-permissive mouse, rabbit and monkey cells were stably transformed by BK virus (BKV). The specificity of transformation was demonstrated by the presence of BKV tumour (T) antigen in nuclei of transformed cells and by virus rescue with Sendai virus-mediated fusion or transfection. Two out of seven BKV-transformed cell lines were oncogenic. Permissive human cells were only abortively transformed by BKV, since morphologically modified cells persisted in culture for a few passages and eventually died.

Received 10 May 1977; accepted 5 September 1977.


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