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Reduction of Intercellular Adhesiveness of Chick Heart Cells by Herpes Simplex Viruses 1 and 2

Department of Pediatrics, Infectious Diseases and Immunology Division and Department of Anatomy, Interdepartmental Study Program in Cell and Molecular Biology, Emory University School of Medicine, Atlanta, Georgia 30322, U.S.A.

Infection with herpes simplex viruses type 1 or 2 prevented the aggregation of 7-day-old chick heart cells into smooth, spheroidal, spontaneously beating aggregates. Virus infection also caused a loosening of peripheral cells in aggregates formed from initially uninfected cells. Measurements of rate of attachment of labelled single heart cells to a monolayer of like cells (homotypic), to HEp-2 cells (heterotypic), or to plastic substrata (nonspecific adhesion) indicated that virus infection caused a significant but differential loss of homotypic and nonspecific adhesiveness, but no alteration in heterotypic attachment rates. These observations indicate that those cell surface changes induced by viruses which are related to cell adhesion can be quantified by techniques measuring attachment rates.

^* Present address: Biosystems, Inc., P.O. Box 15146, Atlanta, Georgia 30333, U.S.A.

Received 22 April 1977; accepted 19 September 1977.