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Radioimmunoassay and Some Properties of Human Antibodies to Hepatitis B Core Antigen

The Lindsley F. Kimball Research Institute of The New York Blood Center, New York, New York 10021, U.S.A.

A solid-phase radioimmunoassay for antibodies to hepatitis B core antigen (anti-HB_c) is described. Polystyrene beads coated with anti-HB_c, hepatitis B core antigen prepared from pooled sera of humans infected with hepatitis B virus (HBV) and ¹²⁵I-labelled anti-HB_c were used for the test.

Distinct patterns of development and changes of anti-HB_c and their immunologic properties are all related to variations of other markers specific for HBV infections. Knowledge concerning the detailed features of the immune response to hepatitis B core antigen may provide deeper insight into the pathogenesis of HBV infections.

Received 17 August 1977; accepted 10 October 1977.