HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gerin, J. L. Articles by Purcell, R. H. Search for Related Content PubMed PubMed Citation Articles by Gerin, J. L. Articles by Purcell, R. H. Agricola Articles by Gerin, J. L. Articles by Purcell, R. H.

Antigens of Hepatitis B Virus: Failure to Detect HBeAg on the Surfaces of HBsAg Forms

Molecular Anatomy Program Oak Ridge National Laboratory 5640 Fishers Lane Rockville, Maryland 20852

Vincent J. McAuliffe and Robert H. Purcell

Laboratory of Infectious Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda, Maryland 20014, U.S.A.

The particulate forms of HBsAg were analysed for the presence of HBeAG on their surfaces. By immunodiffusion analysis, anti-HBe did not form precipitin bands with the purified forms of HBsAg and hyperimmune guinea pig antisera to these forms did not react with HBeAg. Lines of non-identity were observed between the HBeAg determinants (e₁ and e₂) and the Dane particles and filaments isolated from an HBeAg-positive serum. Finally, anti-HBe failed to precipitate the polymerase-positive subpopulation of Dane particles, indicating that anti-HBe has no direct role in virus neutralization.

Received 14 June 1977; accepted 12 September 1977.