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Structures of Polyoma Virus: on the Histone Component and Virion Core

Département de Microbiologie, Centre Hospitalier Universitaire, Université de Sherbrooke, Sherbrooke, Québec, Canada J1H 5N4

We have observed that purified polyoma virus is able to take up an amount of calf thymus histone equivalent to 10 to 50% of its normal histone content under conditions allowing the binding of considerably lesser amounts of several other proteins. Some of the bound histone could not be released by procedures routinely used for virus purification. We have also found that some of the histone present in purified polyoma virus could be selectively released without major breakdown of virus particles. Possible models for virus structure are discussed in the light of the present and other recent data.

^* Present address: Montreal Cancer Institute, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada H2Z 4K8.

Received 20 April 1977; accepted 3 November 1977.