HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Khan, N. C. Articles by Biswal, N. Search for Related Content PubMed PubMed Citation Articles by Khan, N. C. Articles by Biswal, N. Agricola Articles by Khan, N. C. Articles by Biswal, N.

The Fate of Parental Herpesvirus DNA after Infection with Normal and Photoinactivated Virions

Department of Virology and Epidemiology Baylor College of Medicine Houston, Texas 77030, U.S.A.

The fate of the ³H-dT-labelled parental DNA of normal and photoinactivated herpes simplex virus type 1 (KOS strain) was followed for 8 h after infection. The sedimentation coefficients of parental virus DNA from cells infected with normal virions increased and became associated with the replicative intermediates of HSV-1 DNA. When cultured in 5-bromodeoxyuridine-containing medium, the buoyant density of the normal parental virus DNA shifted to the hybrid region (containing heavy and light molecules) of the caesium chloride density gradient. The parental virus DNA of photoinactivated virions, however, degraded quickly and did not participate in progeny virus DNA replication.

Received 14 July 1977; accepted 21 November 1977.