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Interaction of Ultraviolet-Irradiated Herpes Simplex Virus Type 1 with BSC-1 cells

Laboratory for Molecular Virology Hebrew University-Hadassah Medical School, Jerusalem, Israel

Ultraviolet irradiation of herpes simplex virus (HSV) did not affect the transfer of uncoated virus DNA to the nuclei of infected cells but the synthesis of virus DNA was suppressed. The virus-specific DNA polymerase was synthesized in cells infected with the u.v.-irradiated HF strain of HSV. In cells infected with the u.v.-irradiated KOS strain, the virus DNA polymerase activity was hardly detectable. The two strains of HSV differ in the sensitivity of the virus DNA polymerase gene to u.v.-irradiation.

Received 5 October 1977; accepted 5 December 1977.