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J Gen Virol 39 (1978), 387-390; DOI 10.1099/0022-1317-39-2-387
© 1978 Society for General Microbiology
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Interferon Enhances the Fragility of Lysosomes in L-929 Mouse Fibroblasts

Michael Halbach, Klaus Koschel and Christoph Jungwirth

Institut für Virologie und Immunbiologie der Universität Würzburg, D-8700 Würzburg W. Germany

Infection of interferon-treated L-929 mouse fibroblasts with vaccinia WR virus is followed by severe cytolysis within 3 to 4 h. It is shown that this cytolysis cannot be caused by enzymes released from lysosomes into the cytosol. However, there is evidence that homologous interferon has a noxious effect on lysosomes. This phenomenon appears to be another aspect of the anticellular functions of interferon.

Received 9 September 1977; accepted 8 December 1977.




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