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Relationship of Endogenous Murine Xenotropic Type C Virus Production to Spontaneous Transformation of Cultured Cells

Cancer Research Institute and Department of Medicine, University of California Medical Center, San Francisco, California 94143, U.S.A.

Spontaneous production of endogenous xenotropic viruses by clones of New Zealand Black (NZB) embryo cells occurs at a constant level even after several cell transfers. Foci of cell alteration occur spontaneously in some of the clonal lines after 6 to 10 passages. The amount of virus generated does not correlate with spontaneous transformation of these NZB cells nor of cells from NIH Swiss or BALB/c mice. The data demonstrate an intracellular regulation of xenotropic virus expression which remains stable over several cell generations and differs from that controlling cell transformation.

^* Present address: Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, England.

Received 24 October 1977; accepted 5 December 1977.