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Infection of Cultivated Mouse Peritoneal Macrophages with Lymphocytic Choriomeningitis Virus

Heinrich-Pette-Institut für experimentelle Virologie und Immunologie an der Universität, Hamburg, Martinistrasse 52, 2000 Hamburg 20, Federal Republic of Germany

Lymphocytic choriomeningitis virus strain WE multiplied in cultivated peritoneal macrophages from unstimulated NMRI mice. As revealed by immunofluorescence technique, most cells participated in the infectious process. They were not, however, functionally altered. Morphologically, infected cells contained more cytoplasmic vacuoles, but these were also present, though less numerous, in uninfected ageing cells and in cells having phagocytosed Latex beads. As compared with the WE strain virus, the E-350 (Armstrong) strain multiplied more slowly to lower titres, but the proportion of infected cells was similar.

^* Present address: Department of Microbiology, University of British Columbia, 2075 Wesbrook Mall, Vancouver, B.C./V6T 1W5. Canada.

Received 14 October 1977; accepted 12 January 1978.