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Reactions of Intracellular Crystals of Foot-and-Mouth Disease Virus with Ferritin-tagged Antibody

Plum Island Animal Disease Laboratory, Animal Disease and Parasite Research Division, Agricultural Research Service, U.S. Department of Agriculture, Greenport, New York, U.S.A.

Crystals of intracellular foot-and-mouth disease virus, type A1, were reacted with ferritin conjugated to an A1 antibody, an O2 antibody, and normal -globulin as well as unconjugated ferritin. Specific tagging was demonstrated with both the full and ‘empty’ capsid crystals with type A1 virus and anti-A1 globulin. Anti-O2 ferritin-conjugated globulin, normal ferritin-conjugated -globulin and unconjugated ferritin did not attach to the A1 virus and showed only minimal reaction with tissue fragments and debris. Immunodiffusion in agar gel was used to demonstrate the specificity of the reagents.

Received 19 August 1968; accepted 13 September 1968.