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Ribonucleic Acid Nucleotidyl Transferase Induced in Chick Fibroblasts after Infection with Newcastle Disease Virus

Institut für Virologie, Justus Liebig-Universität, Giessen, Germany

In chick fibroblast cell cultures infected with Newcastle disease virus an RNA-dependent RNA nucleotidyl transferase (RNA polymerase) has been detected which was not found in non-infected cells. The enzyme mainly synthesizes RNA complementary to viral RNA as shown by nearest neighbour analysis and hybridization experiments. In contrast to the influenza virus-induced enzyme the Newcastle disease virus enzyme cannot be inhibited by dextran sulphate. Its synthesis is not inhibited by actinomycin. It is first detectable 3 hr after infection and it has reached its highest activity at 5 hr after infection.

Received 30 September 1968; accepted 19 November 1968.