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Morphological Conversion of ‘Immature’ Rauscher Leukaemia Virus Cores to a ‘Mature’ Form after Addition of the P65–70 (gag Gene Product) Proteolytic Factor

Worcester Foundation for Experimental Biology, Inc. Shrewsbury, Massachusetts 01545, U.S.A.

When the partially purified P65–70 proteolytic factor was added at increasing concentrations to ‘immature’ core sub-particles of Rauscher leukaemia virus (RLV), we observed an increased cleavage of P65–70 (the gag gene product) and P40 (an intermediate cleavage product containing p30) to p30, the major group specific antigen. When examined by electron microscopy the immature cores exhibited a linear decrease in number, with a concomitant increase in the number of mature cores after treatment. Various intermediate structures retaining elements of both immature and mature forms were also observed, suggesting that the in vitro conversion from immature cores to mature cores can occur on a 1:1 basis.

Received 2 November 1977; accepted 3 February 1978.