HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Harrison, T. J. Articles by Williams, J. F. Search for Related Content PubMed PubMed Citation Articles by Harrison, T. J. Articles by Williams, J. F. Agricola Articles by Harrison, T. J. Articles by Williams, J. F.

A Host Range Mutant of Human Adenovirus Type 5 Defective for Growth in Hamster Cells

J. F. Williams

M.R.C. Virology Unit Institute of Virology Church Street Glasgow G11 5JR, Scotland

A host-range mutant of adenovirus type 5, which grows in human cells but not in hamster cells, has been isolated. This mutant is complemented in mixed infection in hamster cells at 38.5 °C by temperature-sensitive mutants of type 5 belonging to seventeen complementation groups, and may constitute a new group. In mixed infection of human cells at 32 °C with the host-range and temperature-sensitive mutants, recombination takes place and by a series of two factor crosses the host-range mutation has been approximately located on the adenovirus genetic map.

^* Present address until September 1978: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, U.S.A.

Present address: Department of Biological Sciences, Mellon Institute, Carnegie-Mellon University, Pittsburg, Pennsylvania 15213, U.S.A.

Received 19 October 1977; accepted 17 January 1978.