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J Gen Virol 40 (1978), 359-371; DOI 10.1099/0022-1317-40-2-359
© 1978 Society for General Microbiology
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Attachment of Herpes Simplex Virus to Neurons and Glial Cells

Anders Vahlne, Brita Nyström*, Mats Sandberg*, Anders Hamberger* and Erik Lycke

The Department of Virology, Institute of Medical Microbiology
the* Institute of Neurobiology, University of Göteborg, Göteborg, Sweden

Cells of brain tissue of rabbits, rats and mice were dissociated and glial cells, neuronal perikarya and synaptosomes were separated by centrifugation on discontinuous Ficoll gradients. HSV was shown to attach well to rat and rabbit glial cells and synaptosomes but not to neuronal perikarya. Of intracerebrally infected mice the fractions with glial cells contained the infective virus. The interactions between HSV and neuronal cells and the implication of the observations on the HSV infection of the nervous system are discussed.

Received 15 November 1977; accepted 1 March 1978.


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