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Metabolism of Myoinositol in Avian and Mammalian Cells Infected with Naked and Enveloped DNA and RNA Viruses

Robert Koch-Institut des Bundesgesundheitsamtes Nordufer 20 D-1000 Berlin 65, Germany

W. R. Willems and R. Rott

Institut fur Virologie, Justus-Liebig-Universität Giessen, 6300 Lahn-Giessen, West Germany

The uptake of ³H-inositol into the pool of free inositol and its incorporation into the lipid phosphatidylinositol have been studied in various avian and mammalian cells infected by different viruses. In all the virus-cell systems investigated, virus infection results in a drastically reduced amount of free ³H-inositol about 3 to 5 h post-infection, demonstrable in the infected cells as compared to the mock-infected controls. In contrast, the incorporation of ³H-inositol into lipid can be enhanced, reduced, or not influenced at all, depending on the virus-cell system under observation.

Received 30 December 1977; accepted 1 March 1978.