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Development of Early Nuclear Antigen in Cytomegalovirus Infected Cells in the Presence of RNA and Protein Synthesis Inhibitors

Department of Pediatrics and Microbiology University of Alabama in Birmingham University Station, Birmingham, Alabama 35294, U.S.A.

Human cytomegaloviruses (HCMV) induce nuclear antigens as early as 1 h after infection as detected by immunofluorescence. Early antigen development occurs in the presence of DNA, RNA, and protein synthesis inhibitors and is dependent on intact viral DNA in the inoculum.

Received 7 October 1977; accepted 2 March 1978.

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