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Comparison of Interferon Action in Interferon Resistant and Sensitive L1210 Cells

Instituut Pasteur van Brabant, B-1040 Brussels, Belgium Département de Biologie Moléculaire, U.L.B., B-1640 Rhode St Genése, Belgium

J. Wérenne

International Institute of Cellular and Molecular Pathology, B-1200 Brussels, Belgium

Translation inhibition, leu-tRNA aminoacylation and double-stranded RNA and ATP dependent phosphorylation were examined in interferon-treated and control cell-free lysates of leukaemic mouse L 1210 R and L 1210 S cells. No differences were observed between the respective interferon-treated and control cell-free extracts, except for the presence of an enhanced 67K dalton phosphoprotein fraction in interferon-treated L 1210 S cell-free extracts. In non-responding cell-free lysates, the lack of stimulation of a 67K dalton phosphoprotein fraction cannot be explained by the presence of an increased level of some inhibitory activity, such as a phosphatase.

^* Present address: U.S.T.L., Service de Biochimie des Protéines, Place E. Bataillon, 34060 Montpellier, France.

Received 23 February 1978; accepted 5 May 1978.