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Mink Lung Cells: A Non-primate Cell Line Highly Susceptible for Varicella-Zoster Virus

Institut für Medizinische Virologie der Universitat Heidelberg, Im Neuenheimer Feld 324

Rolf M. Flugel

Institut fur Virusforschung am Deutschen Krebsforschung-Zentrum, Im Neuenheimer Feld 280 69 Heidelberg, W. Germany

Mink lung cells (MvILu) are highly susceptible to varicella-zoster virus (VZV). The titres of cell-free VZV suspensions reached 1.0 x 10⁷ p.f.u./ml at 3 days post-infection, with subsequent cell degeneration, if MvILu cells were infected with a multiplicity of infectious virus of 0.01 p.f.u./cell. In contrast, during the same period and under the same conditions the titres of cell-free VZV were 10² to 10³ times lower when grown on human foreskin fibroblasts. A fast and reliable plaque assay and a neutralization test for VZV on MvILu cells, were developed.

Received 28 March 1978; accepted 15 May 1978.