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J Gen Virol 41 (1978), 189-192; DOI 10.1099/0022-1317-41-1-189
© 1978 Society for General Microbiology

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The ocr Gene Function of Bacterial Viruses T3 and T7 Prevents Host-controlled Modification

D. H. Krüger, G. Gola, Ilona Weisshuhn and Sigrid Hansen

Institute of Virology Humboldt University, Schumannstr. 20/21 DDR — 104 Berlin, German Democratic Republic

On pre-infection of the host Escherichia coli B with u.v.-inactivated T3 or T7 phage able to express their early genes (like 0.3), B-specific modification of super-infecting, successfully multiplying viruses does not take place. The ocr gene function (gene 0.3) of T3 and T7 not only prevents host-specific DNA restriction but also modification, probably by inhibiting the same late step in the interaction between the restriction enzyme and DNA.

Received 1 February 1978; accepted 22 May 1978.


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Copyright © 1978 by the Society for General Microbiology.