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J Gen Virol 41 (1978), 97-104; DOI 10.1099/0022-1317-41-1-97
© 1978 Society for General Microbiology
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Protection of Mice Against Viral Infection by Corynebacterium parvum and Bordetella pertussis

H. Kirchner*, M. T. Scott{dagger}, H. M. Hirt* and K. Munk*

* Institute of Virus Research, Germany Cancer Research Centre, Heidelberg, Federal Republic of Germany, and
{dagger} Department of Experimental Immunobiology, The Wellcome Research Laboratories, Beckenham, Kent, U.K.

Mice could be significantly protected against infection with herpes simplex virus (HSV) by i.p. or i.v. injection of killed Corynebacterium parvum 7 days before infection. This protection was seen in inbred strains of mice with a different degree of sensitivity to HSV and after both i.p. and i.v. infection. Resistant mice immuno-suppressed by X-irradiation and showing an increased susceptibility to HSV could also be protected by a previous injection of C. parvum. Elevated levels of interferon were demonstrated in the serum of mice injected with C. parvum 5 to 12 days previously. Four different strains of anaerobic coryneforms were compared and only those which were able to induce a systemic activation of the lymphoreticular system (as reflected by splenomegaly) protected against HSV infection. Protection against HSV-infection could also be demonstrated by using killed Bordetella pertussis. C. parvum also protected against Semliki Forest virus infection in two different strains of mice.

Received 31 January 1978; accepted 9 May 1978.




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Copyright © 1978 by the Society for General Microbiology.