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J Gen Virol 42 (1979), 185-187; DOI 10.1099/0022-1317-42-1-185
© 1979 Society for General Microbiology
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Assessment of the Interferon-Like Activity in Preparations of Leukocyte Pyrogen

Dianne S. Elfenbein, Patrick A. Murphy, P. Joan Chesney, Dexter S. Y. Seto and David H. Carver

Departments of Pediatrics and Microbiology The Johns Hopkins University School of Medicine, Baltimore, Md. 21205, U.S.A.

Preparations of crude leukocytes from rabbit peritoneal exudates contain interferon-like activity which may be separated from pryogen activity both by Sephadex chromatography and by purification of the pyrogen. This indicates that, despite some similarities, leukocyte pyrogen is not an interferon.

Received 4 July 1977; accepted 25 July 1978.




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Copyright © 1979 by the Society for General Microbiology.