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The Matrix Protein Gene Determines Amantadine-Sensitivity of Influenza Viruses

Division of Virology National Institute for Medical Research, Mill Hill, London NW7 1AA and Wellcome Research Laboratories Langley Court, Beckenham, Kent, U.K.

The genetic composition of several recombinant strains, produced by mixed infection with an amantadine-sensitive and an amantadine-resistant influenza virus, have been compared with their response to amantadine. It is concluded that transfer of resistance or sensitivity to amantadine is determined by a single gene, that coding for the matrix protein.

Received 29 June 1978; accepted 28 July 1978.

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