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Further Studies on Rabies Postexposure Prophylaxis in Mice: a Comparison of Vaccine with Interferon and Vaccine

S. Denise Baughcum

Hilton B. Levy

George M. Baer

Viral Zoonoses Branch Virology Division, Bureau of Laboratories Centre for Disease Control (Lawrenceville Facility) Public Health Service U.S. Department of Health, Education and Welfare, P.O. Box 363, Lawrenceville, Georgia 30246

Mice were inoculated in the left hind footpad with street rabies virus, and 24 h later various types of rabies vaccine were administered intramuscularly in the right leg. The vaccines alone were ineffective in reducing mortality, but when an interferon inducer, polyriboinosinic acid-polyribocytidylic acid complexed to poly-L-lysine (polyICLC), was given along with the vaccines, a marked reduction resulted. The polyICLC-vaccine combination was effective even when it was injected 5 days after infection, suggesting that effective postexposure treatment in man might be successful when given at a comparable late time.

^* Present address: Sección de Rabia, Instituto Nacional de Investigaciones Veterinarias, Maracay, Venezuela.

Present address: College of Veterinary Medicine, University of Georgia, Athens, Georgia, U.S.A.

Present address: Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. 20014, U.S.A.

To whom reprint requests should be addressed, at Lawrenceville.

Received 4 May 1978; accepted 30 August 1978.