HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correction (v43,pNP) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Blalock, J. E. Articles by Baron, S. Search for Related Content PubMed PubMed Citation Articles by Blalock, J. E. Articles by Baron, S. Agricola Articles by Blalock, J. E. Articles by Baron, S.

Mechanisms of Interferon Induced Transfer of Viral Resistance Between Animal Cells

Department of Microbiology, University of Texas Medical Branch, Galveston, Texas 77550, U.S.A.

The sequence of events initiated by interferon and leading to the antiviral state were studied as possible sites for the cell-to-cell transfer of interferon induced viral resistance. The possible role of interferon produced by recipient cells was negated by the demonstration of transfer of resistance in the presence of anti-human interferon antibody and under conditions of a single cycle of VSV growth. Transfer of sensitivity of WISH cells to mouse interferon, possibly through transfer of a membrane receptor, seems unlikely since resistance was transferred in the absence of mouse interferon. From kinetic data and the fact that actinomycin D blocked resistance in human cells for 3 h longer than in mouse cells, it seems unlikely that the mouse antiviral protein itself or its mRNA alone is a likely candidate for the transfer of resistance. Thus, by a process of elimination, we suggest that secondary messenger molecules which transmit the interferon signal from the membrane to the nucleus are the effector substance(s) for the transfer process.

Received 10 April 1978; accepted 30 August 1978.

This article has been cited by other articles:

				R. Lloyd, J. Blalock, and G. Stanton Cell-to-cell transfer of interferon-induced antiproliferative activity Science, September 2, 1983; 221(4614): 953 - 955. [Abstract] [PDF]