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SV40-Transformed Human Diploid Cells that Remain Transformed throughout Their Limited Lifespan

Department of Microbiology and Immunology, Division of Biology and Biomedical Sciences, Washington University School of Medicine, St Louis, Missouri 63110, U.S.A.

Of ninety-one subcultured foci of SV40-transformed WI-38 human diploid fibroblasts, none yielded cells that grew indefinitely, but all cells in each subculture continued to produce T antigen and to look morphologically transformed throughout their lifespan. These results are consistent with the commitment theory of fibroblast senescence, but predict that a special transformation event is necessary to account for the rare survivors.

Received 2 June 1978; accepted 13 September 1978.