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Interferon Susceptibility of Various Cell Lines Persistently Infected with Haemagglutinating Virus of Japan (HVJ)

Nagoya University School of Medicine, Showa-Ku, Nagoya, Japan
^* Germfree Life Research Institute and 1st Department of Internal Medicine,

Various cell lines persistently infected with para-influenza 1 virus, HVJ strain, were less susceptible to the antiviral action of interferon than the same cell lines when not infected with HVJ. When Vero cells persistently infected with a temperature-sensitive strain of HVJ were incubated at 38 °C, a non-permissive temperature, they became fully susceptible to interferon, whereas neither the haemadsorbing nor the cell-associated haemagglutinating activity of the virus was expressed. These findings suggest that the lowered interferon susceptibility of virus-carrier cells may be related to the maturation of virus in them.

It was found that the low susceptibility of virus-carrier cells to interferon is not due to blocked adsorption of interferon or to inability of the cells to respond to interferon. Studies with actinomycin D suggest that some step (or steps) before the synthesis of the messenger RNA for the antiviral protein is blocked.

Received 9 May 1978; accepted 6 October 1978.

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