J Gen Virol
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J Gen Virol 43 (1979), 457-461; DOI 10.1099/0022-1317-43-2-457
© 1979 Society for General Microbiology
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The Effect of Inhibitors of Glycosylation on Interferon Production in Human Lymphoblastoid Cells

B. Cundliffe and J. Morser

Department of Biological Sciences University of Warwick Coventry CV4 7AL, U.K.

Interferon production was inhibited in the Namalwa line of human lymphoblastoid cells by treatment with 2-deoxy-D-glucose or D-glucosamine. D-Glucosamine also inhibited protein synthesis and the cells were no longer viable, whereas 2-deoxy-D-glucose allowed protein and RNA synthesis to continue at control rates, and the cells remained fully viable. It is concluded that a glycosylation step is essential for production of lymphoblastoid interferon.

Received 11 September 1978; accepted 20 December 1978.




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