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The Toxic effect of Double-stranded RNA for Interferon-treated L Cells: Studies on Membrane Transport and with Cell-Free Systems

Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, U.K.

We have tested two possible explanations for the toxic effects observed in L cells treated with interferon followed by poly(rI).poly(rC), namely (1) that the toxicity was preceded by and due to a change in membrane permeability which could be monitored by measurement of ion fluxes, or (2) that the toxicity was due to the action of the inhibitors of protein synthesis which are known to be formed when extracts from interferon-treated cells are treated with poly(rI).poly(rC) in vitro. Neither explanation was found to be correct.

^* Present address: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.

Received 7 August 1978; accepted 30 November 1978.