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Presence of Virus-specific DNA Sequences in Murine Type C Viruses

J. Boaz

D. E. Kohne

Department of Biological Sciences, University of Warwick, Coventry, U.K.
Scripps Institute of Oceanography, La Jolla
La Jolla Cancer Research Foundation, La Jolla, Calif., U.S.A.

Total nucleic acids prepared from a number of murine retroviruses have been shown to contain virus-specific DNA in addition to genomic RNA. This virus-specific DNA has been shown to be at least partially double stranded and to be present within the virus core particle. The DNA isolated from the virus is greatly enriched in virus-specific DNA relative to that from virus infected cells.

^* Present address: La Jolla Cancer Research Foundation, Box 1376, La Jolla, Calif., U.S.A.

Received 13 July 1978; accepted 4 December 1978.