HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Schnitzer, T. J. Articles by Gonczol, E. Search for Related Content PubMed PubMed Citation Articles by Schnitzer, T. J. Articles by Gonczol, E. Agricola Articles by Schnitzer, T. J. Articles by Gonczol, E.

Phenotypic Mixing between Murine Oncoviruses and Murine Cytomegalovirus

Imperial Cancer Research Fund Lincoln's Inn Fields, London WC2A 3PX, U.K.

In vitro interactions between murine cytomegalovirus (MCMV) and murine leukaemia viruses (MuLV), two groups of enveloped viruses capable of causing persistent or latent infections in vivo, were examined for evidence of phenotypic mixing. The growth of MCMV in murine cells productively infected with ecotropic MuLV was shown to result regularly in the production of phenotypically mixed particles having the envelope antigens of MuLV and the genome of MCMV [MCMV(MuLV) pseudotypes]. The identity of such pseudotype particles was confirmed by the use of specific anti-MuLV serum and by the demonstration of restriction due to viral interference of penetration of these particles on MuLV-infected murine cells. This restriction was independent of N- or B-tropism. The production of reverse pseudotypes could not be examined because of the lytic effects of MCMV on the requisite assay cells.

^* Present address: Department of Microbiology, Medical School of Debrecen, Debrecen, Hungary.

Received 8 September 1978; accepted 9 January 1979.