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SV40-Related T-Antigen Expression in Human Meningiomas with Normal and G-22-Monosomic Karyotype

Institut für Humangenetik der Universität des Saarlandes, 6650 Homburg, W. Germany and Institut für Virusforschung Deutsches Krebsforschungszentrum, 6900 Heidelberg, W. Germany

Six of 16 meningiomas tested in early subcultures by indirect immunofluorescence showed SV40 T-antigen. Two different antisera specific for T-antigen were used. One serum gave a positive reaction with six tumours and the other with only two. In one T-antigen positive meningioma, the typical nuclear fluorescence changed, beginning with the second subculture, into an unusual brilliant granular pattern irregularly distributed over the nuclei. In six meningiomas, a specific chromosome aberration (monosomy G 22) was established. However, up to now, no clear correlation between karyotype and T-antigen expression could be found: cells from three meningiomas with positive reactions had normal karyotypes, whereas those from three tumours with typical chromosome loss showed no T-antigen.

Received 12 November 1978; accepted 12 January 1979.