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Ribonuclease Activity of Preparations of Human Lymphoblastoid Interferon

Department of Health, Education & Welfare National Cancer Research Institute Baltimore Cancer Research Program, 655 W. Baltimore Street, Baltimore, Md 21201, U.S.A.

R. A. Winchurch

The Johns Hopkins University The Baltimore City Hospitals, 4940 Eastern Avenue, Baltimore, Md 21224, U.S.A.

C. J. Burman and K. H. Fantes

Department of Virology Wellcome Research Laboratories Langley Court, Beckenham, Kent BR3 3BS, England

Crude human lymphoblastoid interferon has less ribonuclease activity than equivalent primary leukocyte interferon and ribonuclease was eliminated when it was purified. The methods used differed from those that had failed to eliminate similar activity from leukocyte interferon. This result makes it unlikely that exogenous ribonuclease plays a major role in the antiviral action of interferon preparations.

Received 19 January 1979; accepted 13 February 1979.