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J Gen Virol 44 (1979), 323-331; DOI 10.1099/0022-1317-44-2-323
© 1979 Society for General Microbiology
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Studies of the Effect of Chloramphenicol, Ethidium Bromide and Camptothecin on the Reproduction of Rous Sarcoma virus in Infected Chick Embryo Cells

Lorraine Leblond-Larouche*,{dagger},, Réjean Morais*,{dagger}, and Max Zollinger{dagger}

* Institut du Cancer de Montréal, Centre Hospitalier Notre-Dame, Montréal (Qué.) Canada
{dagger} Départment de Biochimie, Université de Montréal, Montréal (Qué.) Canada

A function for mitochondria in the reproduction of Rous sarcoma virus (RSV) in chronically and newly infected chick embryo cells was studied by using chloramphenicol and ethidium bromide. Chloramphenicol (CAM) and ethidium bromide (EB) were both shown to decrease the rate of growth of infected chick embryo cells and to inhibit the synthesis of mitochondrial macromolecules. Both drugs however had little or no effect on the incorporation of labelled leucine, thymidine and uridine into total cellular macromolecules. Neither CAM (80 µg/ml) nor EB (0.4 µg/ml) inhibited the production of infectious virus. In contrast, camptothecin, an inhibitor of cellular but not mitochondrial macromolecular synthesis, was shown to depress the production of infectious virus. The results indicate that the mitochondrial macromolecular synthesis machinery of RSV-infected chick embryo cells does not contribute to virus production.

Received 15 September 1978; accepted 16 January 1979.


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