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Latent Cytomegalovirus Infection of BALB/c Mouse Spleens Detected by an Explant Culture Technique

Department of Health, Education and Welfare Food and Drug Administration Bureau of Biologics, Division of Virology, 8800 Rockville Pike Bethesda, Md. 20014, U.S.A.

Latent murine cytomegalovirus (MCMV) infection of BALB/c mouse spleens was studied using several methods including an explant tissue culture technique, co-cultivation on allogeneic and syngeneic cell cultures and nucleic acid hybridization. BALB/c mice experience latent infection which persists for at least 6 months and involves only a small fraction of spleen cells. The explant culture technique proved to be much more sensitive than other methods for detecting latent infection of lymphoid tissues.

Received 4 January 1979; accepted 20 March 1979.

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