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J Gen Virol 45 (1979), 171-175; DOI 10.1099/0022-1317-45-1-171
© 1979 Society for General Microbiology
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Non-specific Adsorption of Interferon to Immobilized Serum Immunoglobulin

K. E. Mogensen* and K. Cantell{dagger}

* Institut de Recherches Scientifiques sur le Cancer, Villejuif, France
{dagger} Central Public Health Laboratory, Mannerheimintie 166, SF00280 Helsinki, Finland

Human leukocyte interferon attaches to hyperimmune serum immunoglobulins, coupled to agarose, even though the antibodies are not specific for interferon. Unless it is first washed off with ethylene glycol, the attached interferon elutes together with immune-specific antigens during immuno-affinity chromatography.

Received 20 November 1978; accepted 17 April 1979.




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Copyright © 1979 by the Society for General Microbiology.