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Adenovirus-associated Virus Structural Protein Sequence Homology

H. M. Lee^2,

F. B. Johnson^1,

¹ Department of Microbiology, Brigham Young University, Provo, Utah, U.S.A.
² Department of Microbiology, Mt. Sinai School of Medicine, New York City, N.Y., U.S.A.
³ Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Md., U.S.A.

Adenovirus-associated virus (AAV) structural proteins (VP1, VP2, and VP3) have been examined to determine if areas of sequence homology exist between these three virion proteins. Tryptic and chymotryptic maps have been produced which demonstrate extensive areas of sequence homology common to all three proteins. The amino acid compositions of the proteins were also determined and were found to be very similar. These data are consistent with the hypothesis that all three virion proteins arise either from a common precursor or similar transcripts.

^* Present address: Department of Microbiology, Mt Sinai School of Medicine, New York City, N.Y., U.S.A.

Present address: American Cyanimid Co., Clifton, N.J., U.S.A.

Author to whom reprint requests should be addressed.

Received 13 February 1979; accepted 14 May 1979.